Clinical Information

All allergens are reported down to a cutoff level of 0.10 kU/L. The significance of allergen specific IgE levels between 0.10 and 0.35 kU/L remains undefined. Cumulative levels of multiple allergen specific IgE antibodies may have an additive effect in producing clinical symptoms.

Individual allergen specific IgE antibody levels may not always correlate with severity of clinical symptoms. Results must be interpreted in the context of the clinical history and the patient’s symptom presentation. Quantitative IgE levels can serve to guide overall disease management by targeted trigger exposure reduction to identified allergens.

Allergens with a high risk of anaphylaxis (egg, milk, soy, wheat, nuts, seafood, kiwi fruit, latex, insect venoms, drugs) are reported with a reference range of <0.10 kU/L, lower than the <0.35 kU/L reference range used for other routine allergens. IgE antibody levels to these allergens less than 0.10 kU/L do not exclude the possibility of an anaphylactic reaction to the allergen involved, since in vitro assays are indicators of previous sensitization rather than predictors of future response. IgE antibody levels must be interpreted in the context of the clinical history of the patient and the reaction history involved.