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Epic Code LAB1230357 Soluble Liver Antigen (SLA) Autoantibody

Additional Codes

Mayo code: FSLAA

Reporting Name

SLA Autoantibody

Clinical Information

Anti-soluble liver antigen antibodies are detected in 10-30% of patients with type 1 autoimmune hepatitis (AIH), but not in patients with type 2 AIH, primary sclerosing cholangitis or primary biliary cirrhosis. The antibody is directed against a UGA suppressor tRNA associated protein. In some patients with AIH, this antibody may be the only autoantibody detected by current assays.

Performing Laboratory

Quest Diagnostics Nichols Institute

Specimen Required


Specimen Required


Specimen Type: Serum

Container/Tube: Red or SST

Specimen Volume: 1mL

Collection Instructions: Draw blood in a plain red-top tube(s), serum gel tube(s) is acceptable. Spin down and send 1 mL of serum refrigerated in a plastic vial.


Laboratory Test Directory Note:

+S/PO/R

COLLECTION NOTE: Volumes listed are in serum or plasma, draw approximately 2 1/2 times the requested volume in whole blood.

Specimen Type

Serum

Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 8 days
  Frozen  28 days
  Ambient  48 hours

Day(s) Performed

Wednesday

Reject Due To

Hemolysis Mild OK; Gross reject
Lipemia Mild OK; Gross reject
Icterus NA
Other Microbially contaminated serum; Heavy visible particulate in specimen

Reference Values

Reference Range: Negative 0.0-20.0 U

                         Equivocal 20.1-24.9 U

                        Positive >25.0 U

 

Antibodies to soluble liver antigen (SLA) appear to be directed against the UGA-suppressor tRNA associated protein. These antibodies are highly specific for autoimmune hepatitis (AIH) and may rarely, be the only autoantibodies detected in serum from such patients. Antibodies  to SLA are most closely associated with AIH type 1; the presence of these antibodies  in patients with cryptogenic hepatitis suggests that these patients may have AIH type 1.

 

Anti-SLA antibodies may be detected in some patients with the primary biliary cirrhosis-AIH overlap syndrome, but not in healthy controls.

 

Method Name

Enzyme Linked Immunosorbent Immunoassay (ELISA)

CPT Code Information

83520

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FSLAA SLA Autoantibody 32219-8

 

Result ID Test Result Name Result LOINC Value
FSLAA SLA Autoantibody 32219-8

Report Available

2 to 13 days

NY State Approved

Yes

Secondary ID

57735

Forms

If not ordering electronically, complete, print, and send Gastroenterology and Hepatology Client Test Request (T728) with the specimen.