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HelpEpic Code LAB1230663 MyoMarker 3 Profile
Performing Laboratory
Esoterix EndocrinologySpecimen Type
SerumSpecimen Required
Collection Container/Tube: 10 mL Red
Submission Container/Tube: Plastic vial
Specimen Volume: 5 mL
Acceptable: SST
Collection Instructions: Draw blood in a plain red-top tube(s), serum gel tube is acceptable. Separate serum from cells within 1 hour of collection and send 5 mL of serum refrigerated in a plastic vial.
COLLECTION NOTE: Volumes listed are in serum or plasma, draw approximately 2 1/2 times the requested volume in whole blood.
Specimen Minimum Volume
4 mL (volume does NOT allow for repeat testing)
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 60 days | ||
| Ambient | 7 days |
Reject Due To
| Gross hemolysis: | Reject |
| Thawing: | Warm OK; Cold OK |
| Gross lipemia: | Reject |
| Gross icterus | Reject |
| Other: | Anything other than serum; bacterial contamination |
Reference Values
Anti-PL-7 Ab, Anti-PL-12 Ab, Anti-EJ Ab, Anti-OJ Ab, Anti-SRP Ab, Anti-Mi-2-Ab, Anti-U3 RNP (Fibrillarin), Anti-U2 RNP Ab, Anti-Ku Ab:
Reference Range: Negative
Interpretation for:
Anti-Jo-1 Ab, Anti-TIF-1gamma Ab, Anti-MDA-5-Ab (CADM-140), Anti-NXP-2 (P140) Ab, Anti-PM/Scl-100 Ab, Anti-SS-A 52kD Ab IgG, Anti-U1-RNP Ab:
Reference Range: <20
Negative: <20 units
Weak Positive: 20-39 units
Moderate Positive: 40-80 units
Strong Positive: >80 units
Clinical Information
The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of disorders characterized by muscle weakness, resulting from chronic muscle inflammation of unknown cause. Patients with IIM have a variety of autoantibodies with various clinical utilities that fall into two main groups. One group of autoantibodies are found in patients with myositis and are known as Myositis Specific Autoantibodies (MSA). The MSAs are highly specific for patients with polymyositis (PM) dermatomyositis (DM), anti-synthetase syndrome and necrotizing myositis. The second group of autoantibodies are considered Myositis Associated Autoantibodies (MAA). These appear in myositis overlap syndrome and in other connective tissue diseases, which correlate with certain clinical and/or pathophysiological conditions.
Reporting Name
MyoMarker 3 ProfileMethod Name
Enzyme-linked immunosorbent assay (ELISA); RIPA Gel Radiography
CPT Code Information
83516 x 9
86235 x 7
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| FMYO3 | MyoMarker 3 Profile | Not Provided |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| Z5677 | Anti-Jo-1 Ab | 35333-4 |
| Z5678 | Anti-PL-7 Ab | 33772-5 |
| Z5679 | Anti-PL-12 Ab | 33771-7 |
| Z5680 | Anti-EJ Ab | 45149-2 |
| Z5681 | Anti-OJ Ab | 45152-6 |
| Z5682 | Anti-SRP Ab | 33921-8 |
| Z5683 | Anti-Mi-2-Ab | 18485-3 |
| Z5684 | Anti-TIF-1gamma Ab | 88739-8 |
| Z5685 | Anti-MDA-5 Ab (CADM-140) | 88725-7 |
| Z5686 | Anti-NXP-2 (P140) Ab | 82425-0 |
| Z5687 | Anti-PM/Scl-100 Ab | 31562-2 |
| Z5691 | Anti-Ku Ab | 18484-6 |
| Z5692 | Anti-SS-A 52kD Ab, IgG | 70257-1 |
| Z5690 | Anti-U1 RNP Ab | 57662-9 |
| Z5689 | Anti-U2 RNP Ab | 68549-5 |
| Z5688 | Anti-U3 RNP (Fibrillarin) | 49963-2 |