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Epic Code LAB1230919 Bone Alkaline Phosphatase. Serum

Additional Codes

Beaumont Code: LAB6846

Interface Order Alias


Clinical Information

This assay aids in the diagnosis of metabolic bone diseases including Paget disease, osteomalacia, and other states of high bone turnover. The assay is also useful for monitoring the efficacy of antiresorptive therapies including post-menopausal osteoporosis treatment.

This assay is not a screening test for osteoporosis. Diagnosis of osteoporosis should be made on the basis of bone density.

Liver-derived Alkaline Phosphatase (ALP) has cross-reactivity in this assay: approximately 100 U/L of liver ALP gives a result of 2.5-5.8 mcg/L. Therefore, specimens with significant elevations of liver ALP activity may yield elevated bone ALP results.

Collection Instructions

Container(s): Gold top (Serum Separator SST) 

Preferred Volume to Collect: 5 mL

Minimum Volume to Collect: 2 mL

Submission Container/Tube:  Plastic vial

Collection Instructions:

  • After collection, gently invert tube 8-10 times.
  • Specimen should be processed within 2 hours – See Processing Instructions below.



PROCESSING INSTRUCTIONS (Laboratory, Outpatient or Off-site collection)

Processed Specimen: Serum

Centrifuge/Spin: Yes

Aliquot: Yes

Processing Instructions:

  • Allow blood to clot for 30 minutes in a vertical position and centrifuge promptly.
  • Within two hours aliquot serum into a plastic transport tube and refrigerate as soon as possible.
  • (+(2)S/PO/R)

Specimen Transport Temperature


Rejection Criteria

Plasma Specimens. 

Severely hemolyzed, lipemic or icteric specimens. 

Specimen Stability

Serum Specimens (Pour-Overs)

Ambient: 2 hours

Refrigerated: 7 days

Frozen: 60 days

Test Frequency

Tuesday, Friday.
Results available within 3 business days.

Reference Range


Age Male (mcg/L) Female (mcg/L)
6 Months - 2 Years 27.7-114.1 29.5-135.6
3-6 Years 27.5-95.9 29.0-100.8
7-9 Years 43.9-131.0 32.2-149.0
10-12 Years 44.1-145.3 39.7-152.7
13-15 Years 24.1-197.9 11.8-127.0
16-17 Years 12.3-118.1 7.7-40.3
18-24 Years 7.3-25.1  
25 Years or Older 3.9-16.8  
≥ 18 Years, Premenopausal   2.0-13.8
≥ 18 Years, Postmenopausal   4.4-19.0



Performing Department


Performing Department Laboratory Location

Beaumont Royal Oak Special Testing Laboratory



Chemiluminescent Enzyme Immunoassay.



CDM Code


Epic Test ID




Reviewed Date