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Please call 616.774.7721 for specimen pick up

 

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Mayo Clinic Laboratories

Epic Code LAB1230929 HLA-B*57:01 Screen for Abacavir Hypersensitivity

Important Note

Send out Corewell Health Reference Laboratory East

Test Name Alias

 CIB57, B57, ABACAVIR HYPERSENSITIVITY, HLA-B*5701 SCREENING

Clinical Information

The FDA recommends that genetic testing for HLA-B*5701 be performed prior to prescribing the reverse transcriptase inhibitor, Abacavir, to HIV patients. The presence of HLA-B*5701 is associated with a drug-induced hypersensitivity reaction to Abacavir that can be prevented with prior genetic screening.

Specimen Requirements

Specimen Collection: Blood

 

Container(s): 6 mL Pink Top (EDTA) or 3 mL Lavender Top (EDTA) or 8.5 mL Yellow Top ACD Tube

Preferred Volume to Collect: Full tube(s)

Collection Instructions:

  • Gently invert EDTA tube(s) 8 - 10 times after collection.

 

Processing Instructions (Laboratory, Outpatient or Off-site collection)

  • Processed Specimen: Whole Blood
  • Centrifuge/Spin: No
  • Aliquot: No
  • Do not refrigerate or freeze specimen. Maintain whole blood at room temperature (20-26°C or 68-78.8°F) prior to transport. Transport to the Laboratory within 72 hours of collection.
  • Transport: Ambient

Rejection Criteria

  • Unlabeled specimens.
  • Specimens drawn in clot, SST, or Heparin tubes.
  • This test will only be performed once in a lifetime for a patient.

Specimen Stability

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Frozen (-80°C): 2 years (DNA)

Test Frequency

Monday – Friday, 7:00 am – 5:00 pm.
Results available within 7 days.

Reference Range

Negative or positive for HLA-B*57:01.

Performing Department

Send Out to Corewell Health East

Performing Department Laboratory Location

Corewell Health Reference Laboratory East - Royal Oak HLA Laboratory

Methodology

Sequence Specific Priming (SSP) for HLA Class I Genotyping.

CPT

81381

CDM Code

81381

Epic Test ID

1230102990

LOINC

50956-2

Reviewed Date

Under review