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HELPFUL LINKS!

 

LAB COMMUNICATIONS 

 

COLLECTION & HANDLING

 

SPECIMEN TRANSPORTATION

Please call 616.774.7721 for specimen pick up

 

GENERAL INFORMATION

 

GENERAL TEST INFORMATION

 

BILLING

 

WEBSITES

Mayo Clinic Laboratories

Epic Code LAB1230930 HLA Class I Disease Association

Test Name Alias

HLA typing, HLA-A, B, C typing, tissue typing, HLA Class I Typing for disease association, HLA-A29 Genotyping (Birdshot Chorioretinopathy), HLA-B27 Genotyping (Spondyloarthropathies), HLA-B51 Genotyping (Bechet's Disease)

Quick Collect

+WB/A
Invert several times to mix well.    
Shipping/Handling Instructions:    Do not refrigerate or freeze specimen. Maintain whole blood at room temperature (20-26°C or 68-78.8°F) prior to transport. Transport to the Laboratory within 72 hours of collection.

Clinical Information

HLA Class I genotyping defines the antigens of the HLA-A, B and C loci of the Major Histocompatibility Complex found on the short arm of chromosome 6. Using DNA extracted from leukocytes, HLA-A, B and C alleles are amplified via PCR using sequence-specific primers. After amplification, the specific HLA antigens are determined by gel electrophoresis. HLA genotyping serves an important role in transplantation and disease association studies.

Clinical Disease

 

Human Immunodeficiency Virus (HIV).

 

Reference

 

  1. Mallal et al. HLA-B*5701 Screening for Hypersensitivity to Abacavir. The New England Journal of Medicine, 358 (6): 568-579, 2008.

Specimen Type

Blood

Collection Instructions

Specimen Collection Criteria

 

Collect: One Yellow-top ACD tube OR one Pink-top OR two Lavender-top EDTA tube.

Invert several times to mix well.

 

Physician Office/Draw Specimen Preparation

 

Do not refrigerate or freeze specimen. Maintain whole blood at room temperature (20-26°C or 68-78.8°F) prior to transport. Transport to the Laboratory within 72 hours of collection.

 

Preparation for Courier Transport

 

Transport: Whole blood at room temperature (20-25°C or 68-77°F).

 

Rejection Criteria

 

  • Unlabeled specimens.
  • Specimens drawn in clot, SST, or Sodium Heparin tubes.

 

In-Lab Processing

 

Maintain specimen at room temperature (20-26°C or 68-78.8°F) until testing.

Specimen Stability

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Frozen (-80°C): 2 years (DNA)

Test Frequency

As needed.
Results typically available within 5 business days.

Reference Range

Interpretation

By report.

Performing Department

HLA

Performing Department Laboratory Location

Royal Oak HLA Laboratory

Methodology

Polymerase Chain Reaction (PCR).

CPT

81373, 81372

CDM Code

CDM

Epic Test ID

1230102599

LOINC

LOINC: 50956-2

Reviewed Date

Under Review 10/29/2024