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Mayo Clinic Laboratories

Epic Code LAB1230940 HLA-DQB1*06:02 Genotyping (Narcolepsy)

Test Name Alias

HLA-DQB1 06:02; NARCOLEPSY; HLA Class II Disease Association; Narcolepsy-Associated Antigen, HLA-DQB1 Typing, Blood

Quick Collect

+WB/A
Invert several times to mix well.    
Shipping/Handling Instructions: Do not refrigerate or freeze specimen. Maintain whole blood at room temperature (20-26°C or 68-78.8°F) prior to transport. Transport to the Laboratory within 72 hours of collection.

Specimen Type

Blood

Collection Instructions

Specimen Collection: Blood

 

Container(s): 6 mL Pink Top (EDTA) or TWO 3 mL Lavender Top (EDTA)

Preferred Volume to Collect: 6.0 mL

Collection Instructions:

  • Gently invert EDTA tube(s) 8 - 10 times after collection.

 

Processing Instructions (Laboratory, Outpatient or Off-site collection)

  • Processed Specimen: Whole Blood
  • Centrifuge/Spin: No
  • Aliquot: No
  • Do not refrigerate or freeze specimen. Maintain whole blood at room temperature (20-26°C or 68-78.8°F) prior to transport. Transport to the Laboratory within 72 hours of collection.
  • Transport: Ambient

 

In-Lab Processing

 

Maintain specimen at room temperature (20-26°C or 68-78.8°F) until testing.

Specimen Stability

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Frozen (-80°C): 2 years (DNA)

Test Frequency

As needed.
Results typically available within 5 business days.

Reference Range

Interpretation by report.

Performing Department

Send out to Corewell Health East 

Performing Department Laboratory Location

Corewell Health East Royal Oak HLA Laboratory

Methodology

Polymerase Chain Reaction (PCR).

CPT

81376

CDM Code

CDM

Epic Test ID

1230102609

Reviewed Date

1/1/2025

Clinical Information

HLA Class II genotyping defines the antigens of the HLA-DRB1 and DQB1 loci of the Major Histocompatibility Complex found on the short arm of chromosome 6. Using DNA extracted from leukocytes, HLA-DRB1 and DQB1 alleles are amplified via PCR using sequence-specific primers. After amplification, the specific HLA antigens are determined by gel electrophoresis for disease association purposes.

Rejection Criteria

Specimens drawn in green, clot, or SST tubes are unacceptable and will not be tested. Unlabeled specimens will be rejected.

Updated Date

3/12/2025 - Clinical Information and Rejection Criteria added