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LAB COMMUNICATIONS 

 

COLLECTION & HANDLING

 

SPECIMEN TRANSPORTATION

Please call 616.774.7721 for specimen pick up

 

GENERAL INFORMATION

 

GENERAL TEST INFORMATION

 

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Mayo Clinic Laboratories

Epic Code LAB1231203 Nucleotidase, 5'

Additional Codes

ARUP: 0080235

Interface:1231203

Test Name Alias

XNUCL

Ordering Instructions

Confirm diagnosis of anti-NMDAR encephalitis. May be used in monitoring treatment response in individuals who are antibody positive.

Collection Instructions

Specimen Collection: Blood

 

Container(s): Gold Top Serum Separator Tube (SST)

Preferred Volume to Collect: Full tube

Minimum Volume to Collect: 2.0 mL

 

Collection Instructions:

  • Gold/Serum: Allow blood to clot for 30 minutes in a vertical position and centrifuge within 2 hours.
  • Mark samples plainly as "acute" or "convalescent."

 

PROCESSING INSTRUCTIONS

Separate serum from cells ASAP or within 2 hours of collection.

Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.15 mL)

Specimen Transport Temperature

Refrigerated

Rejection Criteria

  • CSF or plasma.
  • Contaminated
  • Hemolyzed
  • Severely lipemic

Specimen Stability

After separation from cells

Ambient: 48 hours

Refrigerated: 2 weeks

Frozen: 1 year (Avoid repeated freeze/thaw cycles)

Test Frequency

Available Sun-Sat, reported in 1-3 days after receipt at ARUP Lab

Reference Range

Less than 1:10

Interpretive Data

NMDA receptor antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response. In addition, positive results have been reported in patients with nonautoimmune phenotypes. A negative test result does not rule out a diagnosis of autoimmune limbic encephalitis. Results should be interpreted in correlation with the patients clinical history and other laboratory findings. Serum testing should be paired with CSF testing for improved diagnostic sensitivity.

This indirect fluorescent antibody assay utilizes full-length GluN1 transfected cell lines for the detection and semiquantification of NMDA receptor IgG antibody..

 

If NMDA antibody IgG is positive, then an NMDA antibody IgG titer is reported. Additional charges apply.

Performing Department

Send out to ARUP Ref. Lab

Performing Department Laboratory Location

REFERRAL SEND OUTS

Methodology

Semi-Quantitative Cell-Based Indirect Fluorescent Antibody

CPT

86255; if reflexed, add 86256

CDM Code

3028625561 

Epic Test ID

123010365

LOINC

Component Test Code* Component Chart Name LOINC
2004222 NMDA Receptor Ab IgG CBA-IFA, Serum 80221-5

Reviewed Date

4/2/2025 - Added to catalog