Epic Code LAB1231758 Catecholamines Fractionated by LC-MS/MS, Urine Free
Additional Codes
ARUP: 0080407 CATE UF
Test Name Alias
- Adrenaline
- Dopamine, Random
- Epinephrine, Random
- Fractionation, Catecholamines
- Free Catecholamine Fractionation
- Noradrenaline
- Norepinephrine, Random
Clinical Information
Not recommended for the evaluation of pheochromocytoma or paraganglioma. Use to evaluate clinical symptoms of excess catecholamine secretion. For the assessment of pheochromocytoma or paraganglioma, refer to Metanephrines, Plasma (Free) (0050184) or Metanephrines Fractionated by HPLC-MS/MS, Urine (2007996).
Specimen Requirements
Patient Preparation
Drugs and medications may affect results and should be discontinued for at least 72 hours prior to specimen collection, if possible.
Collect
24-hour or random urine. Refrigerate 24-hour specimen during collection.
Specimen Preparation
Thoroughly mix entire collection (24-hour or random) in one container. Transfer a 4 mL aliquot to an ARUP standard transport tube. (Min: 2.5 mL) Catecholamines are not stable above pH 7. The pH of such specimens must be adjusted by the addition of 6M HCl acid or sulfamic acid prior to transport. A pH less than 2 can cause assay interference.
Specimen preservation can be extended to 1 month refrigerated by performing one of the following:
Option 1: Transfer a 4 mL aliquot to an ARUP standard transport tube and adjust pH to 2.0-4.0 with 6M HCl. (Min: 2.5 mL)
Option 2: Transfer a 4 mL aliquot to an ARUP standard transport tube containing 20 mg sulfamic acid (ARUP Supply #48098), available online through eSupply using ARUP Connect™ or contact ARUP Client Services at 800-522-2787. (Min: 2.5 mL)
Remarks
Record total volume and collection time interval on transport tube and test request form.
Specimen Transport Temperature
Refrigerated.
Rejection Criteria
Specimens preserved with boric acid or acetic acid. Specimens with pH greater than 7.
Specimen Stability
Unpreserved: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Undefined
Preserved: Ambient: Unacceptable; Refrigerated: 1 month; Frozen: 6 months
Test Frequency
Available Sun-Sat, Reporting 2-7 days
Reference Range
Creatinine, Urine - per 24h |
|
Dopamine, Urine - per 24h |
|
Norepinephrine, Urine - per 24h |
|
Epinephrine, Urine - per 24h |
|
Norepinephrine, Urine - ratio to CRT |
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Dopamine, Urine - ratio to CRT |
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Epinephrine, Urine - ratio to CRT |
|
Interpretive Data
Smaller increases in catecholamine concentrations (less than two times the upper limit) usually are the result of physiological stimuli, drugs, or improper specimen collection. Significant elevation of one or more catecholamines (three or more times the upper reference limit) is associated with an increased probability of a neuroendocrine tumor.
Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.
Compliance Category
Laboratory Developed Test (LDT)
Performing Department
Send out to ARUP Ref. Lab
Performing Department Laboratory Location
REFERRAL SEND OUTS
Methodology
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
CPT
82384
CDM Code
Currently Unavailable
Epic Test ID
Currently Unavailable
Reviewed Date
9/16/2024