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Epic Code LAB1231758 Catecholamines Fractionated by LC-MS/MS, Urine Free

Additional Codes

ARUP: 0080407 CATE UF

Test Name Alias

  • Adrenaline
  • Dopamine, Random
  • Epinephrine, Random
  • Fractionation, Catecholamines
  • Free Catecholamine Fractionation
  • Noradrenaline
  • Norepinephrine, Random

Clinical Information

Not recommended for the evaluation of pheochromocytoma or paraganglioma. Use to evaluate clinical symptoms of excess catecholamine secretion. For the assessment of pheochromocytoma or paraganglioma, refer to Metanephrines, Plasma (Free) (0050184) or Metanephrines Fractionated by HPLC-MS/MS, Urine (2007996).

Specimen Requirements

Patient Preparation

Drugs and medications may affect results and should be discontinued for at least 72 hours prior to specimen collection, if possible.

Collect

24-hour or random urine. Refrigerate 24-hour specimen during collection.

Specimen Preparation

Thoroughly mix entire collection (24-hour or random) in one container. Transfer a 4 mL aliquot to an ARUP standard transport tube. (Min: 2.5 mL) Catecholamines are not stable above pH 7. The pH of such specimens must be adjusted by the addition of 6M HCl acid or sulfamic acid prior to transport. A pH less than 2 can cause assay interference.
Specimen preservation can be extended to 1 month refrigerated by performing one of the following:
  Option 1: Transfer a 4 mL aliquot to an ARUP standard transport tube and adjust pH to 2.0-4.0 with 6M HCl. (Min: 2.5 mL)
  Option 2: Transfer a 4 mL aliquot to an ARUP standard transport tube containing 20 mg sulfamic acid (ARUP Supply #48098), available online through eSupply using ARUP Connect™ or contact ARUP Client Services at 800-522-2787. (Min: 2.5 mL)

Remarks

Record total volume and collection time interval on transport tube and test request form.

Specimen Transport Temperature

Refrigerated.

Rejection Criteria

Specimens preserved with boric acid or acetic acid. Specimens with pH greater than 7.

Specimen Stability

Unpreserved: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Undefined
Preserved: Ambient: Unacceptable; Refrigerated: 1 month; Frozen: 6 months

Test Frequency

Available Sun-Sat, Reporting 2-7 days

Reference Range

Creatinine, Urine - per 24h
Age Male (mg/d) Female (mg/d)
3-8 years 140-700 140-700
9-12 years 300-1300 300-1300
13-17 years 500-2300 400-1600
18-50 years 1000-2500 700-1600
51-80 years 800-2100 500-1400
81 years and older 600-2000

400-1300

 

Dopamine, Urine - per 24h
Age ug/d
0-3 years Not established
4-10 years 80-440
11-17 years 100-496
18 years and older 71-485

 

Norepinephrine, Urine - per 24h
Age ug/d
0-3 years Not established
4-10 years 7-65
11-17 years 12-96
18 years and older 14-120

 

Epinephrine, Urine - per 24h
Age ug/d
0-3 years Not established
4-10 years 1-14
11-17 years 1-18
18 years and okder 1-14

 

Norepinephrine, Urine - ratio to CRT
Age ug/g CRT
0-11 months 25-310
1-3 years 25-290
4-10 years 27-110
11-17 years 4-105
18 years and older 0-45

 

Dopamine, Urine - ratio to CRT
Age ug/g CRT
0-11 months 240-1290
1-3 years 80-1220
4-10 years 220-720
11-17 years 120-450
18 years and older 0-250

 

Epinephrine, Urine - ratio to CRT
Age ug/g CRT
0-11 months 0-380
1-3 years 0-82
4-10 years 5-93
11-17 years 3-58
18 years and older 0-20

Interpretive Data

Smaller increases in catecholamine concentrations (less than two times the upper limit) usually are the result of physiological stimuli, drugs, or improper specimen collection. Significant elevation of one or more catecholamines (three or more times the upper reference limit) is associated with an increased probability of a neuroendocrine tumor.

Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.
 

Compliance Category

Laboratory Developed Test (LDT)

 

Performing Department

Send out to ARUP Ref. Lab

Performing Department Laboratory Location

REFERRAL SEND OUTS

Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

CPT

82384

CDM Code

Currently Unavailable

Epic Test ID

Currently Unavailable

Reviewed Date

9/16/2024