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LAB COMMUNICATIONS 

 

COLLECTION & HANDLING

 

SPECIMEN TRANSPORTATION

Please call 616.774.7721 for specimen pick up

 

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Mayo Clinic Laboratories

Epic Code LAB1231867 Mantle Cell Lymphoma Panel

Test Name Alias

IGH/CCND1, t(11;14) by FISH, FISH for Mantle Cell Lymphoma

Interface Order Alias

1231867

Clinical Information

Fluorescence in situ hybridization (FISH) using DNA probes to detect IGH/CCND1 (IGH locus and the Cyclin D1 gene) gene fusion and loss/deletion of TP53/17p13.1 gene region. The IGH/CCND1 dual fusion identifies cells containing t(11;14) with breakpoints at 11q13 and 14q32. Translocation 11;14 and loss/deletion of TP53 gene region can be associated with CLL and Mantle Cell lymphoma.

 

Routine chromosome analysis is performed on all diagnostic samples and is recommended on all bone marrow specimens to exclude abnormalities not identified by the specified FISH probe(s).

Panel Information

Panel Testing Includes:

t(11;14), IGH/CCND1

-17/17p-, TP53

Specimen Type

Blood or Bone Marrow

Collection Instructions

Specimen Collection: Blood or Bone Marrow

 

Container(s): Green Sodium (NA) Heparin Tube

Preferred Volume to Collect:  3.0 mL

Minimum Volume to Collect: 1.0 mL

Neonate Volume to Collect: 1.0 mL

 

Collection Instructions:

  • Collect bone marrow and transfer marrow from syringe to plain green top sodium heparin tube. Keep sample at room temperature and send to the Lab immediately.

  • Collect peripheral blood into a plain green top sodium heparin tube. Keep sample at room temperature and send to the Lab immediately.

 

Processing Instructions (Laboratory, Outpatient or Off-site collection)

If ambient temperature exceeds 80°F or is below 40°F, please send in an insulated container. All samples should be directed to the laboratory as soon as possible.

Transport Temperature: Ambient (Room Temperature)

 

Specimen Stability

Ambient: 3 days (beyond 3 days, specimen viability will be determined by Cytogenetics Lab)

 

Laboratory Retention: primary specimens 4 weeks; refrigerated pellets retained 12 weeks.

Test Frequency

Test Set Up: Monday – Friday 8:00 am – 5:00 pm, Saturday 8:00 am – 3:00 pm. Technologist on call for Sunday set up.

Final report: 2 – 3 days.

Reference Range

An interpretative report will be provided.

Performing Department

Cytogenetics

Performing Department Laboratory Location

Corewell Health Advanced Technology Laboratory (ATL), Grand Rapids, MI

Methodology

Performed by Fluorescence In-Situ Hybridization (FISH). This test was developed and its performance characteristics determined by Spectrum Health Cytogenetics. It has not been cleared or approved by the U.S. FDA. The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes.

CPT

81168, 88271, 88275

CDM Code

3108116801, 3108827102, 3108827501

Epic Test ID

Unavailable

LOINC

Unavailable

Reviewed Date

2/11/2025