Epic Code LAB1231920 Acetylcholine Receptor Binding Antibody

Test Name Alias

LAB1231068 | Quest: 206 | Acetylcholine Receptor (Muscle AChR) Binding Antibody, Muscle AChR, Myasthenia Gravis (MG) | ACHR Bind

Interface Order Alias

1231920

Clinical Information

Acetylcholine Receptor Binding Antibody - Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. AChR binding autoantibodies are diagnostic of MG, and are found in 85-90% of MG patients. This assay aids in the differential diagnosis of conditions with MG-like muscle weakness and in monitoring therapeutic response. If binding antibodies are negative, assays for modulating and blocking antibodies should be considered.

Specimen Requirements

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.

Also acceptable: One plain Red-top tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells . Transfer serum to a plastic transport tube and keep at room temperature (20-26°C or 68-78.8°F).

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and keep at room temperature (20-26°C or 68-78.8°F)

Specimen Transport Temperature

Transport: 1.0 mL serum, room temperature (20-26°C or 68-78.8°F). (Minimum: 0.5mL)

Rejection Criteria

Plasma
Gross hemolysis
Grossly lipemic.
Microbially contaminated
Specimens not collected and processed as indicated.

Specimen Stability

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 14 daysRefrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 30 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Test Frequency

Performed: Tuesday- Saturday.
Results available in 3-4 days.

Reference Range

Negative	≤0.30 nmol/L
Equivocal	0.31-0.49 nmol/L
Positive	≥0.50 nmol/L

Performing Department

Send Outs

Performing Department Laboratory Location

Sent to Quest Diagnostics Nichols Institute- San Juan Capistrano, CA.

Methodology

Radioimmunoassay (RIA)

CPT

80641

LOINC

Unavailable

Reviewed Date

10/31/2025

Orderable Regions