Epic Code LAB1231931 Zinc Protoporphyrin, Blood

Test Name Alias

LAB1230014 | Zinc, ZPP, WB | Quest: 948 | ZPP,Protoporphyrin, Zinc,Free Erythrocyte Protoporphyrin,
Zinc Protoporphyrin (ZPP) WholeBld Ratio

Clinical Information

Elevated ZPP results are seen in early and late iron deficiency, in the anemia of chronic disease erythropoietic protoporphyria, and in chronic lead poisoning (typically when blood lead is greater than 25 mcg/dL). Causes for false elevations include markedly elevated bilirubin and riboflavin. Elevated protoporphyrin (as in erythropoietic protoporphyria) can also increase the ZPP signal. Specimens which are hemolyzed, clotted, or improperly aliquoted can also show false elevations.

Specimen Requirements

Specimen Collection Criteria

Collect (preferred specimen): One Royal Blue-top EDTA tube.

Physician Office/Draw Specimen Preparation

Do not centrifuge or freeze. Maintain whole blood and keep at room temperature (20-26°C or 68-78.8°F) prior to transport.

In-Lab Processing

Do not centrifuge or freeze. Maintain whole blood and keep at room temperature (20-26°C or 68-78.8°F) prior to transport.

Specimen Transport Temperature

Transport: 2.0 mL whole blood and room temperature (20-26°C or 68-78.8°F) (Minimum: 0.5 mL/ Pediatric 0.2 mL)

Rejection Criteria

Frozen specimens.
Clotted specimens.
Hemolyzed specimens.
Specimens not collected and processed as indicated.

Specimen Stability

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 4 days
Refrigerated (2-8°C or 36-46°F): 10 days
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Test Frequency

Performed: Tuesday-Saturday..
Results available in 2days.

Reference Range

Industrial Exposure

<100 mcg/dL

(Refer to current OSHA regulation for exposure criteria.)

Interpretation

For occupational exposure to lead, OSHA requires ZPP whole blood testing reported in units of mcg/dL. For adults, conversion of ZPP units of mcg/dL assumes a hematocrit of 45%.

Performing Department

Send Outs

Performing Department Laboratory Location

Sent to Quest Diagnostics- Wood Dale, IL

Methodology

Hematofluorometry.

CPT

84202

LOINC

33007-6

Reviewed Date

10/31/2025

Orderable Regions