Epic Code LAB1231949 Islet Cell Antibody Screen with Reflex to Titer

Test Name Alias

LAB1231484 | Quest: 36741 | ISLET CELL, Cell Antibody Screen | LAB1231950

Interface Order Alias

1231949

Clinical Information

slet Cell Antibody Screen with Reflex to Titer - Type 1 diabetes is characterized by lymphocytic cell infiltrate of the pancreatic islets. Measurement of GAD-65, ICA-512, and Insulin Antibody is a highly sensitive means to assess risk and predict onset of Type 1 diabetes. There is a correlation between the number of positive antibodies and the antibody titers versus the severity of the autoimmune process.

Specimen Requirements

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells . Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Specimen Transport Temperature

Transport: 2.0 mL serum, refrigerate (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Rejection Criteria

Gross hemolysis.
Grossly lipemic
Grossly icteric
Specimens not collected and processed as indicated.

Specimen Stability

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 48 hours
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 6 months

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Test Frequency

Performed: Monday – Saturday.
Results available in 3-7 days.

Reference Range

Islet Cell Antibody Screen	Negative
Islet Cell Antibody Titer	<5 JDF units

Performing Department

Send Outs

Performing Department Laboratory Location

Sent to Quest Diagnostics- Wood Dale, IL

Methodology

Immunofluorescence Assay (IFA)

CPT

86341

LOINC

Unavailable

Reviewed Date

11/2/2025

Orderable Regions