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Epic Code LAB1231966 Diabetes Mellitus Type 1 Evaluation, Serum

Test Name Alias

LAB1230658 | Quest: 13621 | Diab Type 1 | Insulin Antibodies, Islet-cell Antibodies, GAD65 Antibody, Zinc Transporter 8 Antibody, Diabetes Autoimmune Test Group

Interface Order Alias

1231966

Clinical Information

Note testing includes:

  • Glutamic Acid Decarboxylase 65 Ab
  • Insulin Autoantibody
  • IA-2 Antibody
  • Zinc Transporter 8 (ZnT8) Antibody

 

Diabetes Type 1 Autoantibody Panel - The American Diabetes Association supports using autoantibody (AAb) screening to diagnose T1D. T1D autoantibodies are markers of ongoing damage to insulin-producing beta cells. The four AAbs used in clinical practice to diagnose T1D are: AAbs against insulin (IAA), tyrosine phosphatase IA2 (IA2A), glutamic acid decarboxylase (GAD65), and zinc transporter. Numerous clinical trials demonstrate important clinical benefits associated with detecting T1D using an AAb screening approach.

Clinical guidelines have been established to help identify T1D at its earliest phases and before progression to DKA, providing presymptomatic and symptomatic staging of T1D.

Specimen Requirements

Specimen Collection Criteria

Collect (preferred specimen): Two Gold-top SST tubes.
Also acceptable: Two plain Red-top tubes.

 

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to plastic transport tube and maintain at room temperature (20-26°C or 68-78.8°F) prior to transport.

 

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to plastic transport tube and maintain at room temperature (20-26°C or 68-78.8°F) prior to transport.

Specimen Transport Temperature

Transport: 4.0 mL serum, room temperature (20-26°C or 68-78.8°F). (Minimum: 2.0 mL)

Rejection Criteria

  • Grossly hemolysis
  • Lipemic specimen
  • Icteric specimen
  • Specimens not collected and processed as indicated.

Specimen Stability

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 7 days
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 28 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Test Frequency

Performed:Varies.

Reference Range

Glutamic Acid Decarboxylase 65 Ab

<5 IU/mL

Insulin Autoantibody

<0.4 U/mL

IA-2 Antibody

<5.4 U/mL

Zinc Transporter 8 (ZnT8) Antibody

<15 U/mL

Performing Department

Send Outs

Performing Department Laboratory Location

Sent to Quest Diagnostics- Wood Dale, IL

Methodology

ELISA and Radioimmunoassay • Radiobinding Assay (RBA)

CPT

86337, 86341 x3.

LOINC

Unavailable

Reviewed Date

11/2/2025

Orderable Regions

Send Outs