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Epic Code LAB1231977 Voltage-Gated Calcium Channel AB

Test Name Alias

LAB1231530 | XVGCC | Quest: 34057 | VGCC TYPE P/Q AB, LEMS Autoantibody Test, Lambert-Eaton Myasthenic Syndrome (LEMS), Voltage Gated Calcium Channel IgG (LEMS) Autoantibodies, Lambert-Eaton Test

Interface Order Alias

1231977

Clinical Information

These autoantibodies are found in Lambert-Eaton syndrome, in some patients with cancer without Lambert-Eaton syndrome and in a few patients with other neurological diseases.

Specimen Requirements

Specimen Collection Criteria

Collect (preferred specimen):   One Gold-top SST tube

Also acceptable: . One plain Red-top tube.

 

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

 

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

 

Specimen Transport Temperature

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.2 mL)

Rejection Criteria

  • Gross Hemolysis
  • Lipemia
  • Received room temperature
  • Freeze/thaw greater than 3 cycles.
  • Specimens not collected and processed as indicated

Specimen Stability

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 48 hours
Refrigerated (2-8°C or 36-46°F): 7days
Frozen (-20°C/-4°F or below): 35 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Test Frequency

Performed: Wednesday.
Results available in 4-11 days.

Reference Range

<30 pmol/L

 

Interpretation

Voltage-gated calcium channel (VGCC) autoantibodies are characteristic of Lambert-Eaton Myasthenic Syndrome (LEMS) with or without small-cell lung cancer. VGCC autoantibodies are also found, albeit less frequently and generally in low amounts, in paraneoplastic disease associated with lung, ovarian or breast carcinomas; in carcinomas (without LEMS or other paraneoplastic syndrome) and occasionally in neurological diseases such as amyotrophic lateral sclerosis. This assay detects p-type VGCC autoantibodies using omega-conotoxin M toxin (omega-conotoxin MVIIC).

Performing Department

Send Outs

Performing Department Laboratory Location

Sent to Quest Diagnostics- Wood Dale, IL

Methodology

Radiobinding Assay (RBA)

CPT

86596

LOINC

Unavailable

Reviewed Date

11/2/2025

Orderable Regions

Send Outs