Epic Code LAB1231988 Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G

Test Name Alias

PAI-1 4G/5G Polymorphism,PAI-1 Promoter Polymorphism,Plasminogen Activator Inhibitor-1,PAI-1 (Plasminogen Activator Inhibitor-1) | LAB1231237 | PAI1 4G/5G | Quest: 11368

Interface Order Alias

1231988

Clinical Information

Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G - Plasma plasminogen activator inhibitor, PAI-1 is a major inhibitor of fibrinolysis. The 4G variant (AF386492.2:g.837del) in the PAI-1 (Serpine 1) gene promoter region is associated with an increase in the level of PAI-1 in plasma. Increased levels of PAI-1 in plasma may increase the risk for arterial and venous thrombosis, myocardial infarction, and progression of atherosclerosis and also recurrent spontaneous abortion.

Specimen Requirements

Specimen Collection Criteria

Collect: One Lavender-top EDTA tube.
Also acceptable: One Pink-top(EDTA) tube.

Physician Office/Draw Specimen Preparation

Do not centrifuge. Maintain whole blood room temperature (20-26°C or 68-78.8°F) prior to transport.

Specimen Transport Temperature

Transport: Whole blood room temperature (20-26°C or 68-78.8°F). (Minimum: 3.0 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

Specimen Stability

Whole Blood
Room Temperature (20-26°C or 68-78.8°F): 8 days
Refrigerated (2-8°C or 36-46°F): 8 days
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Test Frequency

Performed: Wednesday, Saturday.
Results available in 7-10 days.

Reference Range

By report.

Interpretation

The PAI-1 promoter 4G/5G polymorphism located in the promoter region of the SERPINE1 gene.

Performing Department

Send Outs

Performing Department Laboratory Location

Sent to Quest Diagnostics- Wood Dale, IL

Methodology

Polymerase Chain Reaction (PCR) and detection.

CPT

81400

LOINC

Not available

Reviewed Date

11/2/2025

Orderable Regions