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Epic Code LAB1232036 Phospholipase A2 Receptor (PLA2R) Antibody Panel

Test Name Alias

LAB1231561, LAB3489, LAB1231562, LAB1231771 | Quest: 93875 |  Primary Membranous Nephropathy,Membranous Nephropathy,Glomerulonephritis,Anti-PLA2R,Idiopathic Membranous Nephropathy,PLA2R Antibodies

Interface Order Alias

1232036

Clinical Information

Phospholipase A2 Receptor (PLA2R) Antibody Panel - Phospholipase A2 Receptor (PLA2R) Antibody (Ab) testing provides physicians with a non-invasive tool for diagnosing primary membranous nephritis (PMN), an autoimmune disease most commonly mediated by autoantibodies to the podocyte antigen, PLA2R. PLA2R Ab is a highly specific biomarker for PMN and is detected in about 70-80% of patients. Moreover, PLA2R Ab levels frequently rise and fall with the clinical course of PMN and PLA2R Ab levels may have clinical utility in monitoring PMN patients for therapeutic response, remission, and disease relapse.

Specimen Requirements

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.

Also acceptable: One plain Red-top tube.

 

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and keep at room temperature (20-26°C or 68-78.8°F) prior to transport.

 

n-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and keep at room temperature (20-26°C or 68-78.8°F) prior to transport.

Specimen Transport Temperature

1.5 mL serum, room temperature (20-26°C or 68-78.8°F) prior to transport.  (Minimum: 1.0 mL)

Rejection Criteria

  • Specimens not collected and processed as indicated.

Specimen Stability

Room Temperature (20-26°C or 68-78.8°F): 7 days
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 21 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Test Frequency

Unavailable

Reference Range

Phospholipase A2 Receptor (PLA2R) Ab, ELISA

RU/mL  
<14 Negative
14-19 Borderline
>19 Positive

 

Phospholipase A2 Receptor (PLA2R) Ab, IFA Negative

Performing Department

Send Outs

Performing Department Laboratory Location

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

Methodology

Enzyme Linked Immunosorbent Assay (ELISA) • Immunofluorescence Assay (IFA)

CPT

83520, 86255

LOINC

PHOSPHOLIPASE A2 RECEPTOR (PLA2R) AB, ELISA 73737-9
PHOSPHOLIPASE A2 RECEPTOR (PLA2R) AB, IFA 82991-1

Reviewed Date

11/17/2025

Orderable Regions

Send Outs