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Epic Code LAB2111352 Prenatal Aneuploid Screen (XY,13,18,21) by FISH

Test Name Alias

AneuVysion (XY,13,18,21) by FISH | Aneuscreen | FISH for major Trisomies | 991

Interface Order Alias

11366

Quick Collect

AP Ambient

Clinical Information

Fluorescence in situ hybridization (FISH) using AneuVysion probe set (VYSIS®) helps detect abnormalities in the copy number of chromosomes 13, 18, 21, X and Y on uncultured amniotic fluid or chorionic villus cells.

Collection Instructions

Multiple specimen collection types. Submit only one:

 

Specimen Collection: Amniotic fluid

Container(s): 2 Sterile screw-capped conical tubes

Preferred volume to collect: 30.0 mL

Minimum volume to collect: 20.0 mL

Collection Instructions:

  • Discard first 2 mL to prevent contamination with maternal cells.
  • 5 – 10 mL will be used for FISH and remaining fluid for chromosome studies.

 

Specimen Collection: Chorionic Villus

Container(s): Sterile transport tube with tissue culture media

Preferred volume to collect: 15 mg

Processing Instructions (Laboratory, Outpatient or Off-site collection)

Spin: No

Aliquot: No

 

Transport Temperature: Ambient

 

If ambient temperature exceeds 80°F or is below 40°F, please send in an insulated container. All samples should be directed to the laboratory as soon as possible.

Specimen Stability

Ambient: 3 days (beyond 3 days, specimen viability will be detemined by Cytogenetics Lab)

Laboratory Retention: primary specimens 4 weeks; frozen pellets retained greater than 1 year

Test Frequency

Test Set Up: Monday – Friday 8:00 am – 5:00 pm, Saturday 8:00 am – 3:00 pm.

Technologist on call for Sunday set up.

Final report: 1 – 2 days.

Reference Range

An interpretative report will be provided.

Performing Department

Cytogenetics

Performing Department Laboratory Location

Corewell Health Advanced Technology Laboratory (ATL), Grand Rapids, MI

Methodology

Performed by fluorescence in situ hybridization (FISH). This test was developed and its performance characteristics determined by Spectrum Health Cytogenetics. It has not been cleared or approved by the U.S. FDA. The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes.

CPT

88271 x5, 88274 x2

CDM Code

3108827102, 3108827401

Epic Test ID

1230100337

LOINC

Specimen Type: 66746-9

Indication Provided: 42349-1

Result: in process

Interpretation: 59050-5

Comments: 69965-2

Reviewed Date

4/28/2023