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Epic Code LAB2111439 XX and XY (includes SRY) by FISH

Important Note

Please review Ordering Instructions

Test Name Alias

XX and XY (includes SRY) by FISH | Gender Indentification | 974

Interface Order Alias


Quick Collect

AP Ambient

Clinical Information

Fluorescence in situ hybridization (FISH) using DNA probes to enumerate X and Y chromosomes and detect the presence of SRY (male sex determining gene). This is especially helpful with gender identification in those patients with ambiguous genitalia.

Ordering Instructions

XX and XY (includes SRY) by FISH is a predictive and presymptomatic genetic test.


Submission of an order for any predictive genetic tests and presymptomatic genetic tests, as defined by MCL 333.17020, contained in this catalog constitutes certification to Corewell Health laboratories that the ordering physician understands that written, informed consent is required for these tests and that, by submitting an order for these genetic tests, ordering physician has obtained “Informed Consent” of subject patient as required by any applicable state or federal laws with respect to each test ordered. On occasion, we forward a specimen to an outside reference laboratory. Corewell Health laboratories may request that ordering physician provide such consent to Corewell Health upon a reasonable request.


For an example of an informed consent, click here.

Collection Instructions

Specimen Collection: Blood


Container(s): 4.0 mL Green top Sodium (Na) Heparin

Preferred Volume to Collect: 4.0 mL

Minimum Volume to Collect: 1.0 mL

Neonate Volume to Collect: 1.0 mL

Capillary collect ok: No

Microtainer acceptable: No


Collection Instructions:

  • Gently invert 8 times to mix anticoagulant with blood.

Processing Instructions (Laboratory, Outpatient or Off-site collection)

Processed Specimen: Whole Blood

Centrifuge/Spin: No

Aliquot: No


Processing Instructions:

  • If ambient temperature exceeds 80°F or is below 40°F, please send in an insulated container.

Transport Temperature: Ambient

Specimen Stability

Ambient: 3 days (beyond 3 days, specimen viability will be detemined by Cytogenetics Lab)

Laboratory Retention: primary specimens 4 weeks; frozen pellets retained greater than 1 year

Test Frequency

Test Set Up: Monday – Friday 8:00 am – 5:00 pm, Saturday 8:00 am – 3:00 pm.

Technologist on call for Sunday set up.

Final report: 3 – 5 days.

Reference Range

An interpretive report will be provided.

Performing Department


Performing Department Laboratory Location

Corewell Health Advanced Technology Laboratory (ATL), Grand Rapids, MI


Performed by fluorescence in situ hybridization (FISH). This test was developed and its performance characteristics determined by Spectrum Health Cytogenetics Laboratory. It has not been cleared or approved by the US FDA. The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes.


88271 x3, 88275

CDM Code

3108827102, 3108827501

Epic Test ID



Specimen Type: 66746-9

Indication Provided: 42349-1

Result: in process

Interpretation: 59050-5

Comments: 69965-2

Reviewed Date