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Epic Code LAB263 HPV (Human Papilloma Virus) High Risk Screen

Important Note

  • The APTIMA HPV Assay has only been validated for use with cervical specimens collected in PreservCyt Solution using a broom-type or cytobrush/spatula collection device.
  • If only HPV is needed and collected with Thin Prep, please order Primary HPV [LAB1230723]

Test Name Alias

Human Papilloma Virus High Risk Only | HPV | 241 | HPV HRS | HPV DNA | HPV High Risk Screen

Interface Order Alias


Quick Collect


Clinical Information

Testing is performed using the APTIMA HPV nucleic acid amplification test for the qualitative detection of E6/E7 viral messenger RNA (mRNA) from 14 high-risk human papillomavirus (HPV) types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68) in cervical specimens collected in ThinPrep PreservCyt Solution. Results are reported as positive or negative as the test does not determine the specific HPV type present or provide a quantitative viral load. The use of this test is indicated: 1. In women 30 years and older, with the results used in combination with cervical cytology to assess the presence or absence of high-risk HPV types, to guide patient management. 2. In women 21 years or older with atypical squamous cells of undetermined significance (ASC-US) cervical cytology results to determine the need for referral to colposcopy. The results of this test are not intended to prevent women from proceeding to colposcopy.

Specimen Requirements

Specimen Type: Cervical
Container/Tube: ThinPrep Pap Test vials containing PreservCyt Solution
Volume: 4.0 mL
Minimum volume: 1.0 mL

Specimen Transport Temperature


Specimen Stability

Ambient: 30 days

Refrigerated: 105 days

Frozen: 24 months

Laboratory Retention: 30 days

Test Frequency

Available Monday through Friday, usual TAT after receipt in Cytology Department 1-5 days

Reference Range

Negative for the 14 High Risk (HR) HPV types listed below.

Performing Department


Performing Department Laboratory Location

Corewell Health Reference Laboratory, Grand Rapids, MI


Aptima HPV


The APTIMA HPV HR Assay is an in vitro nucleic acid amplification test for the qualitative detection of

E6/E7 viral messenger RNA (mRNA) from 14 high-risk types of human papillomavirus (HPV) in

cervical specimens.



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