Clinical Information

Severe Combined Immunodeficiency Disorder (SCID) is a group of genetically heterogeneous disorders which affect the immune response. The immunological phenotype involves primarily T cell impairment and T cell lymphopenia, however, the B cell and NK cell lineages may also be affected.  Patients with SCID are very susceptible to life threatening infection like pneumonia, meningitis, or blood infections, making early diagnosis imperative in order to reduce morbidity and mortality.  This flow cytometry assay may be ordered on infants with a positive TREC Screen in order to determine quantities of B cells and T cell subsets, including CD45RA naïve and CD45RO memory cells.