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Epic Code LAB3507 Lung Cancer Mutation Analysis

Test Name Alias

Lung Cancer Panel | 7030

Interface Order Alias


Quick Collect

AP Ambient

Clinical Information

This panel is designed to follow the current National Comprehensive Cancer Network (NCCN) guidelines for non-small cell lung cancer by evaluating EGFR, ALK and other driver genetic alterations using multiplex testing. Targeted agents may be available for treatment based on the genetic alteration profile identified.


Tissue sections were examined by pathological review for relevant tumor area for analysis.  DNA-based next generation sequencing (NGS) was performed using Archer® VariantPlex to detect frequently occurring mutations in exons 18-21 of the EGFR gene, exons 2-4 of the KRAS gene, exon 15 of the BRAF gene, exon 20 of the ERBB2 gene, and high-level MET amplification. RNA-based NGS was performed using Archer® FusionPlex platform to detect MET exon 14 skipping events along with prominent ALK, NTRK, RET, and ROS1 fusions. This test also has the potential to uncover additional genetic alterations on MET, BRAF, FGFR1/2/3, NRG1 fusion and EGFRvIII if present. These rare alterations must be integrated into the clinical context for interpretation for limited specimens were available for validation.

Specimen Requirements

Submit only one of the following specimens:



Specimen Type:  Formalin-fixed, paraffin-embedded (FFPE) tissue (block and 10 unstained slides) accompanied by an H&E slide scribed by Pathologist and Surgical Specimen Testing order sheet (Refer to the "Resources" section to the left).

Specimen Collection:  Place specimen in 10% Formalin and order Tissue Pathology in addition to Lung Cancer  Mutation Analysis order.



Also Acceptable:

Specimen Type:  Pleural Fluid

Specimen Collection:  Place specimen in sterile container and order Medical Cytology in addition to Lung Cancer Mutation Analysis order.


Also Acceptable:

Specimen Type:  Fine Needle Aspirate (such as lymph node)

Specimen Collection:  Order FNA Cytology (refer to test code 202 for collection instructions) in addition to Lung Cancer Mutation Analysis order.

Specimen Transport Temperature


Reflex Information

Mandatory Reflex Information:

●   All newly diagnosed lung (non-small cell) adenocarcinomas, Lung Cancer Mutation Analysis

Test Frequency

Usual TAT 5-10 days

Reference Range

An interpretative report will be provided

Performing Department

Molecular Diagnostics

Performing Department Laboratory Location

Corewell Health Advanced Technology Laboratory (ATL), Grand Rapids, MI


Performed by next generation sequencing (NGS) and fluorescence in situ hybridization (FISH).



CDM Code


Epic Test ID



LOINC code unavailable at this time

Mayo Access Code


Reviewed Date