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Mayo Clinic Laboratories

Epic Code LAB477 Levetiracetam Level

Test Name Alias

Keppra

Interface Order Alias

10822

Collection Instructions

Specimen Collection: Blood

 

Container(s): Red top (no additive)

Preferred Volume to Collect: 3.0 mL

Minimum Volume to Collect: 2.0 mL

Neonate Volume to Collect: 2.0 mL

Capillary collect ok? Yes

Microtainer acceptable?  Yes

 

Collection Instructions:

  • After collection, gently invert tube 8-10 times.
  • Specimen should be processed – See Processing Instructions.

Processing Instructions (Laboratory, Outpatient or Off-site collection)

Processed Specimen: Serum

Centrifuge/Spin: Yes

Aliquot: Yes

 

Processing Instructions:

  • When tubes are clotted (30-45 minutes), centrifuge specimens
  • Pipette serum into aliquot tube

Minimum serum volume: 1.0 mL

 

Transport Temperature: Ambient

Specimen Stability

Ambient: 72 hours

Refrigerate: 7 days

Frozen: 14 days

Laboratory Retention: 7 days

Test Frequency

Available 24 hours, usual TAT 1 day.

STAT TAT 2 hours

 

Reference Range

CHW

  • Normal range is 6 to 46 µg/mL
  • Normal range is derived from trough samples

 

Brivaracetam (Briviact®) interferes with measurements of levetiracetam (Keppra®) in the ARK Levetiracetam Assay. Patients undergoing a switch in drug therapy involving Keppra and Briviact should not be monitored for levetiracetam using the ARK assay. Serum levels of levetiracetam and/or brivaracetam should be confirmed by a valid chromatographic method if there is a possibility these drugs are co-present in circulation.

 

CHS

12.0 - 46.0 mcg/mL

  •  

Performing Department

Toxicology

Performing Department Laboratory Location

CHW: Corewell Health Reference Laboratory, Grand Rapids, MI
CHS: Corewell Health Lakeland St. Joseph Laboratory, St. Joseph, MI

Methodology

Colorimetric

CPT

80177

CDM Code

3018017701

Epic Test ID

1230100884

LOINC

Levetiracetam Lvl: 30471-7

Mayo Access Code

SHO3140

Reviewed Date

3/25/2025

Updated Date

5/20/2025 - CHS info added