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Epic Code LAB681 Amitriptyline Level

Test Name Alias

Elavil | Tryptanol | Endep | Tryptizol | Laroxyl | Trepiline | Saroten | Triptyl | Redomex | 8251

Interface Order Alias


Collection Instructions

Specimen Collection: Blood


Container(s): Red top (no additive) or Gray top (Oxalate and Sodium Fluoride)

Preferred Volume to Collect: 3.0 mL

Minimum Volume to Collect: 1.0 mL

Neonate Volume to Collect: 1.0 mL

Capillary collect ok? Yes

Microtainer acceptable: Yes


Collection Instructions:

  • After collection, gently invert tube 8-10 times.
  • Red top is preferred tube.
  • Specimen should be processed  – See Processing Instructions.

Processing Instructions (Laboratory, Outpatient or Off-site collection)

Processed Specimen: Serum or Plasma

Centrifuge/Spin: Yes

Aliquot: Yes


Processing Instructions:

  • Red top:
    • When tubes are clotted (30-45 minutes), centrifuge specimens
    • Pipette serum into aliquot tube
  • Gray top:
    • Centrifuge after collection
    • Pipette plasma into aliquot tubes

Minimum plasma/serum volume: 0.5 mL


Transport Temperature: Ambient

Specimen Stability

Ambient: 72 hours

Refrigerate: 7 days

Frozen: 14 days

Laboratory Retention: 7 days

Test Frequency

Available 24 hours, usual TAT 1-3 days.

STAT TAT 4 hours.


Reference Range

Combined Amitriptyline and NortriptylineTherapeutic Range: 80 – 250 ng/mL

Performing Department


Performing Department Laboratory Location

Corewell Health Reference Laboratory, Grand Rapids, MI


Liquid Chromatography-Mass Spectrometry


This test was developed and its performance characteristics determined by Spectrum Health Toxicology Laboratory. It has not been cleared or approved by the FDA. The laboratory is regulated under CLIA as qualified to perform high-complexity testing. This test is used for clinical purposes. It should not be regarded as investigational or for research.




80335, G0480

CDM Code


Epic Test ID



Amitriptyline Lvl: 3333-2

Nortriptyline Lvl: 3872-9

Mayo Access Code


Additional Information

Gold Top SST not acceptable

Reviewed Date