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Epic Code LAB7130 Cryoglobulin, Serum

Important Note


Test Name Alias

Cryoglobulins | 8128

Interface Order Alias


Quick Collect


Clinical Information

This test was developed and its performance characteristics determined by Spectrum Health Laboratory. It has not been cleared or approved by the FDA. The laboratory is regulated under CLIA as qualified to perform high-complexity testing. This test is used for clinical purposes. It should not be regarded as investigational or for research.

Collection Instructions

Specimen Collection: Blood

Container(s): Red Top (Plain, No additive) x 4

  • Preferred Volume to Collect: 24.0 mL
  • Minimum Volume to Collect: 8.0 mL
  • Neonate Volume to Collect: 8.0 mL
  • Capillary collect ok: Yes
  • Microtainer acceptable: Yes

Collection Instructions:

  • Deliver to lab immediately after collection.
  • During transportation keep the tubes wrapped in an activated Instant Hot Pack- Medium to maintain at or near body temperature before and during the clotting process.
  • Recommend that outpatient specimens be drawn at a Hospital Laboratory.


Processing Instructions (Laboratory, Outpatient or Off-site collection)


Processed Specimen: Serum

Centrifuge/Spin: Yes

Aliquot: Yes

Processing Instructions:

  • Upon receipt in the lab, transfer the tubes to a 37º C water bath. Do not completely immerse the tubes under water, but the water level must surround the blood level in the tube.
  • After tubes clot (approx. 45 mins) centrifuge for 5 minutes, combine serum into one tube and centrifuge again.
  • Transfer serum to plastic transport tube and refrigerate.
  • This specimen must be free of all red cells.

Transport Temperature: Refrigerate after processing

Specimen Stability

Deliver to laboratory immediately. Refrigerate after processing.

Reflex Information

Mandatory Reflex Testing:

  • Positive Cryoglobulin which have not had an identification in the past 2 months will have Reflex Cryoglobulin Interpretation ordered.


Test Frequency

Available Monday through Friday, usual TAT 4-7 days.

Reference Range

No cryoglobulin detected.


Positive cryoglobulin reported with Pathologist interpretation

Performing Department


Performing Department Laboratory Location

Corewell Health Reference Laboratory, Grand Rapids, MI


Positive cryoglobulin are identified using agarose gel immunofixation


Additional charges for pathologist interpretations may apply.

CDM Code


Epic Test ID



Cryoglobulin: 5117-7

Cryo 0 Hr: N/A

Cryo 24 Hr: N/A

Mayo Access Code


Reviewed Date