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Epic Code LAB753 Clozapine and Metabolite Level

Test Name Alias

Clozaril | 8045 | Norclozapine

Interface Order Alias


Collection Instructions

Specimen Collection: Blood


Container(s): Red top (no additive) or Gray Top (Potassium Oxalate and Sodium Fluoride) 

Preferred Volume to Collect: 3.0 mL

Minimum Volume to Collect: 1.0 mL

Neonate Volume to Collect: 1.0 mL

Capillary collect ok? Yes

Microtainer acceptable?  Yes


Collection Instructions:

  • After collection, gently invert tube 8-10 times.
  • Specimen should be processed – See Processing Instructions.


Processing Instructions (Laboratory, Outpatient or Off-site collection)


  • Processed Specimen: Serum
  • Centrifuge/Spin: Yes
  • Aliquot: Yes
  • Processing Instructions:
    • When tubes are clotted (30-45 minutes), centrifuge specimens
    • Pipette serum into aliquot tube
  • Minimum serum volume: 0.5 mL
  • Transport Temperature: Ambient

Specimen Stability

Ambient: 72 hours

Refrigerate: 7 days

Frozen: 14 days

Laboratory Retention: 7 days

Test Frequency

Available 24 hours, usual TAT 1-3 days.

Reference Range

Clozapine: 300 – 700 ng/mL

Norclozapine: Not well established 

Performing Department


Performing Department Laboratory Location

Corewell Health Reference Laboratory, Grand Rapids, MI


Liquid Chromatography-Mass Spectrometry


This test was developed and its performance characteristics determined by Spectrum Health Toxicology Laboratory. It has not been cleared or approved by the FDA. The laboratory is regulated under CLIA as qualified to perform high-complexity testing. This test is used for clinical purposes. It should not be regarded as investigational or for research.




CDM Code


Epic Test ID



Clozapine Lvl: 6896-5

Mayo Access Code


Additional Information

Gold Top SST not acceptable

Reviewed Date