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Epic Code LAB848 Somatostatin (Somatotropin Release-Inhibiting Factor, SRIF)

Important Note

  • Order as Reference Miscellaneous #LAB848; indicate complete test name when ordering.
  • Requires special collection tubes. Prior to ordering, please contact the Spectrum Health Laboratory Referrals Department (616-267-2753).
  • Fasting specimen required (10 - 12 hours)
  • Patient should not be on any medications that affect insulin secretion or intestinal motility, if possible for at least 48 hours prior to collection.

Additional Codes

Mayo Code: FSOMA

Performing Laboratory

Inter Science Institute

Specimen Type

GI Plasma


Specimen Required


1. Patient should be fasting 10 to 12 hours prior to collection.

2. Patient should not be on any medications that affect insulin secretion or intestinal motility, if possible, for at least 48 hours prior to collection.

Specimen Type: GI Plasma

Container/Tube:

Preferred: EDTA tube containing GI preservative (T125)

Acceptable: EDTA purple top plasma tube

Specimen Volume: 3 mL

Collection Instructions:

1. Collect 10 mL of blood in special tube containing GI Preservative (T125), EDTA purple-top plasma tube is acceptable.

2. Specimen should be separated immediately.

3. Send 3 mL plasma frozen as soon as possible.


Laboratory Test Directory Note:

COLLECTION NOTE: Volumes listed are in serum or plasma, draw approximately 2 1/2 times the requested volume in whole blood.

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
GI Plasma Frozen 180 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Day(s) Performed

Monday through Friday

Reference Values

Up to 25 pg/mL

Clinical Information

Somatostatin is a cyclic peptide originally isolated from sheep hypothalami and shown to inhibit the release of Growth Hormone. Somatostatin is present primarily in three main forms: a 14 amino acid peptide, a 28 amino acid peptide ("Big" Somatostatin), and a 12,000 molecular weight Pro-somatostatin. This assay measures only the 14 amino acid form of somatostatin. All three forms of somatostatin have similar biological properties and overall potencies. Somatostatin is a physiological regulator of islet cell and gastrointestinal functions and is a suppressor of many pituitary hormones including Growth Hormone, Prolactin, and Thyrotropin (TSH). Somatostatin levels are often elevated in diabetics, but the levels return to normal upon correction of the hormonal and metabolic deficiencies present. In many cases of APUDomas including VIPoma, Insulinoma, Glucagonoma, and Gastrinoma, elevated levels of Somatostatin are found.

Reporting Name

Somatostatin (Plasma)

Method Name

Direct Radioimmunoassay (RIA)

CPT Code Information

84307

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FSOMA Somatostatin (Plasma) 2961-1

 

Result ID Test Result Name Result LOINC Value
Z0933 Somatostatin, (Plasma) 2961-1

Report Available

9 to 11 days

Test Classification

This test was developed and its performance characteristics determined by Inter Science Institute. It has not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.