Sign in →

Browse by Name

  1. A
  2. B
  3. C
  4. D
  5. E
  6. F
  7. G
  8. H
  9. I
  10. J
  11. K
  12. L
  13. M
  14. N
  15. O
  16. P
  17. Q
  18. R
  19. S
  20. T
  21. U
  22. V
  23. W
  24. X
  25. Y
  26. Z
  27. #
 

 

HELPFUL LINKS!

 

LAB COMMUNICATIONS 

 

COLLECTION & HANDLING

 

SPECIMEN TRANSPORTATION

Please call 616.774.7721 for specimen pick up

 

GENERAL INFORMATION

 

GENERAL TEST INFORMATION

 

BILLING

 

WEBSITES

Mayo Clinic Laboratories

Epic Code LAB1230573 Monoclonal Gammopathy Screen

Test Name Alias

Protein Electrophoresis IFE if Indicated | SPEP | Immunofixation | Kappa and Lambda serum free light chains

Interface Order Alias

1230573

Clinical Information

The Monoclonal Gammopathy Screen reflects expert recommendations for the first line testing for monoclonal gammopathies (plasma cell proliferative disorders).  If amyloidosis (AL) is suspected, first line testing should also include Protein Electrophoresis, 24 Hour Urine, do IFE if Indicated (LAB2111444). For guidance on ordering protein and urine electrophoresis, please refer to Orders- Protein Orderable Changes. 

 

Panel Information

This panel includes:

 

Ordering Instructions

Protein Electrophoresis cannot be ordered a second time within a 2 week window in Laboratory Information System (LIS)

 

Collection Instructions

Specimen Collection: Blood

Container(s): Gold Top (Serum Separator-SST Gel)

  • Preferred Volume to Collect: 5.0 mL
  • Minimum Volume to Collect: 2.0 mL
  • Neonate Volume to Collect: 2.0 mL
  • Capillary collect ok: Yes
  • Microtainer acceptable: Yes

Collection Instructions:

  • Fasting specimen preferred but not required.
  • Gently invert gold tube(s) 8 - 10 times to mix clot activator with blood.
  • Specimen should be processed within 2 hours – See Processing Instructions.

 

Processing Instructions (Laboratory, Outpatient or Off-site collection)

 

Processed Specimen: Serum

Centrifuge/Spin: Yes

Aliquot: No

Processing Instructions:

  • Allow blood to clot for 30 minutes in a vertical position and centrifuge within 2 hours.

Transport Temperature: Refrigerate

Rejection Criteria

  • Specimen not processed within 2 hours
  • Protein Electrophoresis cannot be ordered a second time within a 2 week window in the Laboratory Information System (LIS)

Specimen Stability

Ambient: 8 hours

Refrigerate: 7 days

Laboratory Retention: 7 days

Reflex Information

Reflex approved by Medical Executive Committee. Please see link: Reflex Testing Document

Test Frequency

Available Monday – Friday, TAT up to 5 business days depending on if the specimen needs additional testing.

Reference Range

Kappa and Lambda Free Light Chains

Kappa Free Light Chain: ≥18 Years: 0.33 – 1.94 mg/dL

Lambda Free Light Chain: ≥18 Years: 0.57 – 2.63 mg/dL

Kappa Lambda FLC Ratio: ≥18 Years: 0.26 – 1.65 mg/dL

 

Serum Protein Electrophoresis

Total Protein

0 up to 8 Days: 4.5 – 7.0 g/dL

8 Days up to 3 Years: 5.5 – 7.5 g/dL

>3 Years: 6.0 – 8.0 g/dL

Protein Fractions

Albumin: 3.7 – 4.9 g/dL

Alpha 1 Globulin: 0.2 – 0.4 g/dL

Alpha 2 Globulin: 0.5 – 0.9 g/dL

Beta Globulin: 0.6 – 1.0 g/dL

Gamma Globulin: 0.6 – 1.4 g/dL

Performing Department

Immunochemistry

Performing Department Laboratory Location

Corewell Health Reference Laboratory, Grand Rapids, MI

Methodology

See individual tests for Methodology

CPT

84165 x2  for Serum protein electrophoresis : Technical and Professional billing
86334 x2 for reflex Serum immunofixation: Technical and Professional billing
83521 x2 for Kappa/Lambda

CDM Code

3018416501; 3018352101; 3028633401

Epic Test ID

1230100856, 1230101084, 1230101084

LOINC

Unknown

Mayo Access Code

Total Protein in serum:  2885-2
Serum albumin in electrophoresis: 2862-1
Serum alpha 1  globulin in electrophoresis: 2865-4
Serum alpha 2 globulin in electrophoresis: 2868-8
Serum beta globulin in electrophoresis: 2871-2
Serum gamma globulin in electrophoresis:  2874-6
Monoclonal Protein 1, 2 or 3 in serum: each 94400-9
Serum protein electrophoresis interpretation in Pathologist Interpretation field:  49296-7
Serum immunofixation in Pathologist Interpretation field:  49297-5

104544-2:  Kappa
33944-0: Lambda
104546-7:  Kappa Lambda FLC ratio

Reviewed Date

3/4/2025